July 4, 2026 · Journal of cardiac failure · DOI: 10.1016/j.cardfail.2026.06.025

Time to benefit of incretin-based therapies in adiposity-related heart failure with mildly reduced or preserved ejection fraction: a systematic review and meta-analysis

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The authors aimed to determine the time to clinical benefit of incretin-based therapies in patients with adiposity-related heart failure with mildly reduced or preserved ejection fraction. Their systematic review and meta-analysis of four randomized controlled trials revealed that these therapies significantly reduced worsening heart failure events, with sustained benefits observed starting around six months after treatment initiation.

Bernardo F Spiazzi, Carolina P Zingano, Amanda R Vest

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