Anti-CCL2-conjugated platelets attenuate early allograft and ischemia-reperfusion injury by inhibiting monocyte infiltration
Listen to this summary
The authors investigate the role of CCL2-CCR2 signaling in early allograft dysfunction and its contribution to inflammatory injury and rejection in liver transplantation. They develop a platelet-based drug delivery system conjugated with anti-CCL2 antibodies (PLT-aCCL2) to inhibit monocyte infiltration and mitigate these adverse effects. The study demonstrates that targeting this signaling pathway can protect liver allografts by disrupting the immune-inflammatory cascade and reducing interactions between monocytes and T cells.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of hepatology
View all →Jul 11, 2026 · Journal of hepatology
Surveillance of patients at risk of liver cancer: Expert opinions
Jul 8, 2026 · Journal of hepatology
Validation of a pan-ELastography Machine-learning (ELM) score to predict clinically significant portal hypertension in compensated advanced chronic liver disease
Jul 6, 2026 · Journal of hepatology
Ivonescimab plus gemcitabine and cisplatin as first-line therapy for advanced biliary tract cancer: a multicenter, open-label phase 2 trial
Jul 6, 2026 · Journal of hepatology
Declining but persistent hepatocellular cancer risk beyond 10 years of entecavir or tenofovir in chronic hepatitis B: Results of the PAGE-B cohort
Jul 5, 2026 · Journal of hepatology
Durvalumab with gemcitabine-based chemotherapy regimens in advanced biliary tract cancer: primary results from the phase IIIb TOURMALINE study
Jul 1, 2026 · Journal of hepatology
Anserine restores antibacterial immunity in cirrhosis via a protective CCL5-mediated hepatocyte-CD44<sup>+</sup>pDC crosstalk
More in Internal Medicine
View all →Jul 11, 2026 · Journal of addiction medicine
Multiple Substance Use Disorders From Adolescence to Midlife
Jul 11, 2026 · American heart journal
Antegrade dissection and re-entry versus retrograde strategy in chronic total occlusion percutaneous coronary intervention: Rationale and design of the ADRENALINE randomized study
Jul 11, 2026 · Mayo Clinic proceedings
Embedding Ethics Into Decision-Making Capacity Assessment:An EHR-Enabled Systemwide Approach
Jul 11, 2026 · American heart journal
Integrative assessment of high-sensitivity C-reactive protein and lipid levels in predicting 20-year atherosclerotic cardiovascular disease risk, in a Mediterranean population: The ATTICA study (2002-2022)
Jul 11, 2026 · American heart journal
Interpreting apparent differences among the major colchicine trials for cardiovascular prevention: a descriptive compatibility analysis
Jul 11, 2026 · Journal of cardiac failure
An abbreviated exercise right heart catheterization protocol for the diagnosis of heart failure with preserved ejection fraction
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
