Anserine restores antibacterial immunity in cirrhosis via a protective CCL5-mediated hepatocyte-CD44<sup>+</sup>pDC crosstalk
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The authors investigate the immune defects that increase bacterial infection susceptibility in patients with liver cirrhosis, specifically focusing on the dysregulated crosstalk between hepatocytes and CD44<sup>+</sup> plasmacytoid dendritic cells (pDCs). They identify a critical metabolic-immune axis involving the histidine metabolite anserine and CCL5 signaling that is impaired in cirrhosis, and demonstrate that restoring this axis can enhance antibacterial immunity and reduce infection-related mortality. Their findings suggest that anserine supplementation may serve as a potential therapeutic strategy for managing infections in cirrhotic patients.
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