Comparative Analysis of Human and Porcine Corneal Mechanics and Structure after Glycosaminoglycan Degradation
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The authors aimed to compare the biomechanical and microstructural effects of keratan sulfate glycosaminoglycans (GAGs) in human and porcine corneas after enzymatic degradation. They found that human corneas exhibited greater mechanical strength than porcine corneas, and the removal of KS GAGs significantly weakened both types of corneas while altering their microstructural properties. This study highlights the importance of GAGs in maintaining corneal integrity, which could inform future treatments for vision diseases associated with GAG defects.
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