June 16, 2026 · Menopause (New York, N.Y.) · DOI: 10.1097/GME.0000000000002829

FDA safety concerns and menopausal-like symptoms in postmenopausal statin users

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The authors aimed to investigate the relationship between statin therapy and menopausal-like symptoms in postmenopausal women, particularly in light of FDA warnings regarding statin side effects. The study found that statin users experienced significantly more severe menopausal symptoms, musculoskeletal issues, and higher sarcopenia risk compared to non-users, although statin use was not associated with mild cognitive impairment. These findings suggest that the cognitive and physical effects of statins may overlap with menopausal symptoms, potentially increasing the symptom burden for women in midlife.

Juan E Blümel, Peter Chedraui, María S Vallejo, Sócrates Aedo, Gustavo Gómez-Tabares, Álvaro Monterrosa-Castro, Konstantinos Tserotas, Mónica Ñañez, Eliana Ojeda, Claudia Rey, Marcio A H Rodrigues, Doris Rodríguez-Vidal, Carlos Salinas, Andrés Calle, Alejandra Elizalde-Cremonte, Carlos Escalante, María T Espinoza, Maribel Dextre

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