June 10, 2026 · The Journal of urology · DOI: 10.1097/JU.0000000000005156

Water Vapor Therapy for the Management of Prostate Cancer: The VAPOR 2 Study Initial Results of Ablative Efficacy and Toxicity

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The VAPOR 2 study aimed to assess the safety and effectiveness of water vapor therapy for ablating prostate tissue in men with intermediate-risk localized prostate cancer. Initial results from 110 participants indicated that 75% had benign tissue on follow-up biopsy, with a significant reduction in PSA levels and prostate volume, while adverse events were generally mild and resolved without complications. These findings suggest that water vapor therapy may be an effective treatment option with low procedural morbidity for this patient population.

Arvin George, Eric Giesler, Brian Mazzarella, Richard Levin, Daniel Frendl, Christopher Warlick, Robert Given, Naveen Kella, Thomas Frye, Lance Mynderse, Ali Kasraeian, Aaron Milbank, Phillippe Nabbout, Ivan Grunberger, Ardeshir Rastinehad, Michael Schwartz, James Wysock, Michael Rousseau, Marc Pliskin, Raj Satkunasivam, David Rich, Neal D Shore, Jose Moreno, Laurence Belkoff, Abhinav Sidana, Samir S Taneja

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