Inhibition of heat shock protein 90 in the mouse spinal cord enhances opioid antinociception through upregulation of PKCβ in CGRP neurons
Listen to this summary
The authors investigate how the inhibition of heat shock protein 90 (Hsp90) in the spinal cord affects opioid antinociception, specifically examining the role of protein kinase C (PKC) signaling. They find that Hsp90 inhibition enhances opioid pain relief by upregulating PKCβ in calcitonin gene-related peptide (CGRP) neurons, suggesting that targeting Hsp90 could improve opioid therapy by increasing analgesic effects and reducing side effects.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More in Anesthesiology
View all →Aug 7, 2026 · Critical care medicine
Telemedicine Critical Care Billing For Hospitalized Medicare Fee-For-Service Beneficiaries, 2018-2024
Aug 7, 2026 · Critical care medicine
Geographic Access to Care and Mortality in Cardiogenic Shock: A Nationwide Cohort Analysis
Aug 7, 2026 · Anesthesiology
Fragility Index of Randomized Clinical Trials in Perioperative Anesthesia: A Methodological Survey of Guideline-Supporting Evidence
Aug 7, 2026 · Anesthesiology
Effect of Pre-operative Intravenous Crystalloid Bolus on Post-Induction Blood Pressure - a randomized blinded intervention trial
Aug 7, 2026 · Critical care medicine
Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover
Aug 6, 2026 · Critical care medicine
Targeted Temperature Management at 35°C vs. 37°C for Heatstroke in ICU: A Pilot Randomized Controlled Trial
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
