Inhibition of heat shock protein 90 in the mouse spinal cord enhances opioid antinociception through upregulation of PKCβ in CGRP neurons
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The authors investigate how the inhibition of heat shock protein 90 (Hsp90) in the spinal cord affects opioid antinociception, specifically examining the role of protein kinase C (PKC) signaling. They find that Hsp90 inhibition enhances opioid pain relief by upregulating PKCβ in calcitonin gene-related peptide (CGRP) neurons, suggesting that targeting Hsp90 could improve opioid therapy by increasing analgesic effects and reducing side effects.
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