Pain
Pain
Audio Summaries
Every issue of Pain moves the field forward, but reading every paper cover-to-cover isn't realistic. OSLR turns each article into a 3-minute audio summary so you can stay current while you commute, round, or work out.
Recent summaries
The latest articles summarized from Pain.
Lanthionine synthetase C-like protein 1 (LanCL1): a therapeutic target for neuropathic pain
Jun 9, 2026
The authors investigate the role of lanthionine synthetase C-like protein 1 (LanCL1) in chronic neuropathic pain, seeking to determine its potential as a therapeutic target. They demonstrate that the novel peptide ligand LAT8881 effectively reverses mechanical allodynia in rodent models of neuropathic pain by modulating LanCL1 activity, highlighting its critical role in neuropathic hypersensitivity. The study suggests that targeting LanCL1 could offer new avenues for treating neuropathic pain.
Brief cognitive behavioral therapy for chronic pain rapidly improves pain interference: a randomized controlled trial
Jun 9, 2026
The authors aimed to evaluate the effectiveness of brief cognitive behavioral therapy (CBT) for chronic pain in improving pain interference among primary care patients with moderate to severe chronic musculoskeletal pain. Their randomized controlled trial demonstrated that participants receiving brief CBT alongside usual pain care experienced significant and sustained improvements in pain interference, physical quality of life, and sleep quality compared to those receiving usual care alone. This study highlights the potential of abbreviated behavioral treatments to enhance access to care and improve patient outcomes in chronic pain management.
Inhibition of heat shock protein 90 in the mouse spinal cord enhances opioid antinociception through upregulation of PKCβ in CGRP neurons
Jun 9, 2026
The authors investigate how the inhibition of heat shock protein 90 (Hsp90) in the spinal cord affects opioid antinociception, specifically examining the role of protein kinase C (PKC) signaling. They find that Hsp90 inhibition enhances opioid pain relief by upregulating PKCβ in calcitonin gene-related peptide (CGRP) neurons, suggesting that targeting Hsp90 could improve opioid therapy by increasing analgesic effects and reducing side effects.