June 4, 2026 · The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · DOI: 10.1016/j.jagp.2026.05.008

The Impact of Anticholinergic Burden on the Development of Mild Behavioral Impairment

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The authors aimed to investigate the relationship between anticholinergic burden (ACB) and the development of mild behavioral impairment (MBI) in cognitively unimpaired older adults. Their findings indicate that higher ACB scores are significantly associated with an increased risk of developing MBI, suggesting that careful consideration of anticholinergic medication is necessary in this population to mitigate potential neuropsychiatric risks.

Clio E Franklin, Paul B Rosenberg, Constantine G Lyketsos, Zahinoor Ismail, Jeannie-Marie Leoutsakos

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