Developmental Pathways From Genetic Predispositions to Psychopathology in Adolescence
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The authors investigate how genetic predispositions, represented by polygenic scores (PGS) for various psychopathologies, influence the development of psychopathological symptoms from childhood to adolescence. By analyzing two longitudinal cohorts, they find that PGS for neurodevelopmental issues is significantly associated with both baseline and developmental trajectories of psychopathology symptoms, suggesting it may serve as a broad indicator of susceptibility in youth.
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