Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia
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The authors aimed to investigate the global variability in the practice of central nervous system (CNS) staging for pediatric acute lymphoblastic leukemia (ALL) and its implications for treatment decisions. Through a survey of 82 centers across 47 countries, they found significant heterogeneity in practices related to sample handling, testing methodologies, and definitions of test positivity. This variability may contribute to the conflicting evidence regarding the prognostic significance of CNS involvement in ALL, highlighting the need for a global consensus on CNS diagnostics.
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