Guanylyl Cyclase 2C-Targeted Chimeric Antigen Receptor T-Cell Therapy in Patients With Metastatic Colorectal Cancer
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This study aimed to evaluate the safety and efficacy of guanylyl cyclase 2C (GUCY2C)-targeted chimeric antigen receptor T-cell (CAR T) therapy in patients with metastatic colorectal cancer (CRC) who have limited treatment options. The phase I trial demonstrated an acceptable safety profile, with a 26.3% objective response rate and improved outcomes in patients receiving higher doses of CAR T cells, particularly among those with medium-to-high GUCY2C expression.
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