Continuing Glucagon-Like Peptide-1 Receptor Agonists Into the First Trimester of Pregnancy and Pregnancy Outcomes : A Target Trial Emulation Study Using Claims Information
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The authors aimed to assess the risks associated with continuing glucagon-like peptide-1 receptor agonists (GLP-1RAs) during the first trimester of pregnancy, specifically focusing on nonlive birth, abnormal fetal growth, and major congenital malformations (MCM). Their analysis of claims data from 3,572 pregnancies indicated that continuation of GLP-1RAs did not show definitively higher risks for these outcomes compared to noncontinuation, although the estimates for MCM and small for gestational age (SGA) were imprecise and could not rule out clinically significant differences.
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