June 4, 2026 · Urogynecology (Philadelphia, Pa.) · DOI: 10.1097/SPV.0000000000001885

Stool Microbiota, Metabolites, and Fecal Incontinence in Women

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The authors aimed to investigate whether fecal incontinence (FI) in women is linked to higher levels of butyrate and Clostridiales taxa in stool. Their findings revealed no significant differences in butyrate levels or Clostridiales between women with FI and controls; however, they identified novel stool metabolite signatures associated with FI, suggesting potential new biological pathways and therapeutic targets for managing this condition.

Lily A Arya, Purna C Kashyap, Megan U Carnes, Ravi Mathur, Holly E Richter, Uduak U Andy, J Eric Jelovsek, Nazema Y Siddiqui, Casey D Morrow, Elliot J Lefkowitz, William J Van Der Pol, Corey Broeckling, Benjamin Carper, Sarah E S Jeney, Halina M Zyczynski, Keisha Y Dyer, Cassandra Carberry, Donna Mazloomdoost, Marie G Gantz, NICHD Pelvic Floor Disorders Network

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