Single Antibiotic Use with Ceftriaxone for Prophylaxis of All Open Fractures

The authors aimed to evaluate the effectiveness of a prophylactic antibiotic protocol using ceftriaxone for all open fractures compared to a traditional regimen that varied based on fracture type. Their findings indicated that ceftriaxone was non-inferior to the classic protocol regarding deep infection rates and was associated with a shorter time to antibiotic administration, suggesting it may be a safe and efficient standard for treating open fractures. However, the study's power was limited to detect significant differences in deep infection rates.