Prophylactic interventions to prevent rebound pain after peripheral nerve block in adults: a systematic review and network meta-analysis of randomised controlled trials

The authors aimed to evaluate pharmacological strategies to prevent rebound pain after peripheral nerve blocks in adults through a systematic review and network meta-analysis of randomized controlled trials. They found that intravenous dexamethasone was the most effective intervention for reducing the incidence of rebound pain, while perineural dexamethasone and dexmedetomidine were beneficial for delaying its onset and prolonging analgesia. The study underscores the need for further research on alternative strategies due to varying evidence quality.