May 18, 2026 · Arthritis & rheumatology (Hoboken, N.J.) · DOI: 10.1002/art.70223

A Pragmatic Trial of a Shared Decision-Making Intervention to Improve Medication Adherence and Outcomes in Systemic Lupus Erythematosus: The HCQ-SAFE Study

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The HCQ-SAFE study aimed to evaluate the effectiveness of a pictogram-based shared decision-making (SDM) tool in improving hydroxychloroquine (HCQ) adherence and reducing decisional conflict among patients with systemic lupus erythematosus (SLE). The results indicated that the intervention significantly increased adherence rates by 47% among non-adherers and reduced decisional conflict to just 1% post-intervention, demonstrating its feasibility and potential benefits across diverse patient demographics.

Caroline Packee, Jay J Patel, Jessica Kent, Betty Chewning, Sancia Ferguson, Patricia Tellez-Giron, David Gazeley, Christie M Bartels, Shivani Garg

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