"Mechanisms, Magnitude, and Consequence of Acute Estimated Glomerular Filtration Rate Change with Guideline-Directed Medical Therapy Initiation in Heart Failure"

The authors investigate the mechanisms and implications of acute changes in estimated glomerular filtration rate (eGFR) following the initiation of guideline-directed medical therapy (GDMT) in heart failure patients. They highlight that while GDMT can initially cause a transient decrease in eGFR, its long-term use is associated with a slower decline in kidney function and reduced risk of chronic kidney disease. The review emphasizes the importance of collaboration between nephrologists and cardiologists to monitor eGFR changes effectively and implement strategies to optimize the benefits of GDMT.