May 10, 2026 · The American journal of cardiology · DOI: 10.1016/j.amjcard.2026.04.050

Cardiac Magnetic Resonance for the Prediction of Arrhythmic Events in Mitral Valve Prolapse: A Systematic Review and Meta-analysis

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This systematic review and meta-analysis aimed to evaluate the prognostic value of cardiac magnetic resonance (CMR) imaging biomarkers—late gadolinium enhancement (LGE), mitral annular disjunction (MAD), and systolic curling—in predicting arrhythmic events in patients with mitral valve prolapse (MVP). The findings indicated that all three biomarkers were significantly associated with an increased risk of arrhythmias, with LGE showing the best predictive performance. The study highlights the potential of CMR in risk stratification for MVP patients, suggesting a need for further research on management strategies for those with LGE.

Christos A Papanastasiou, Polydoros N Kampaktsis, Zoi Papalamprakopoulou, Thomas Gossios, Theofilos Panagiotidis, Maria-Anna Bazmpani, Thomas Zegkos, Damianos N Kokkinidis, Stefanos Votsis, Ioannis Tziatzios, Despoina Parcharidou, Vasileios Kamperidis, Georgios Efthimiadis, Andreas A Giannopoulos, Apostolos Tsapas, Antonios Ziakas, Theodoros D Karamitsos

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