Transcatheter Tricuspid Valve Intervention Versus Optimal Medical Therapy in Symptomatic Tricuspid Regurgitation: A Systematic Review and Meta-Analysis of Randomized and Observational Studies

The authors aimed to compare the clinical outcomes of transcatheter tricuspid valve intervention (TTVI) versus optimal medical therapy (OMT) in patients with symptomatic tricuspid regurgitation (TR). Their systematic review and meta-analysis of 13 studies found that TTVI was associated with reduced all-cause mortality compared to OMT, although this benefit was not confirmed in analyses restricted to randomized controlled trials. The findings suggest that TTVI may be a viable treatment option for high-risk patients with symptomatic TR, but caution is warranted due to potential confounding in non-randomized studies.