Lipoprotein(a) Distribution Across Race/Ethnicity and Association with Mortality Outcomes in NHANES III (1988-1994) with Follow‑Up to 2019

This study investigates how the association between lipoprotein(a) [Lp(a)] levels and mortality outcomes varies across different race/ethnicity groups in a multi-ethnic cohort of U.S. adults from NHANES III. The authors found that Lp(a) concentrations were highest in non-Hispanic Black participants, and while higher Lp(a) levels were linked to increased cardiovascular mortality in Mexican Americans, this association was not observed in non-Hispanic White participants. The findings suggest the need for race/ethnicity-specific Lp(a) risk thresholds to improve cardiovascular risk stratification.