Real World Outcomes of Pembrolizumab and Reduced-Dose Lenvatinib in Recurrent Endometrial Cancer by Platinum and p53 Status
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This study aimed to evaluate the efficacy of pembrolizumab and reduced-dose lenvatinib in patients with recurrent endometrial cancer, specifically examining outcomes based on platinum resistance and p53 mutation status. The findings indicated that a lower starting dose of lenvatinib (≤10 mg) was non-inferior to higher doses in terms of objective response rate and was better tolerated, while p53 mutation status was associated with improved progression-free survival. These results support the potential for individualized dosing strategies and highlight p53 mutation as a possible predictive biomarker in this patient population.
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