May 7, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102092

Malignant transformation of a testosterone-secreting ovarian steroid cell tumor: a case report

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This case report investigates the malignant transformation of a testosterone-secreting ovarian steroid cell tumor (SCT-NOS) in a 41-year-old woman, initially presenting with benign features but later developing malignant characteristics after three years. The authors aim to highlight the potential for malignant recurrence in SCT-NOS, the associated molecular alterations, and the challenges in managing such cases despite surgical and chemotherapeutic interventions. The findings underscore the need for improved risk stratification and novel treatment strategies for this rare tumor type.

Ravi Desai, Daniel Bravo, Pelin Onur, Berrin Ustun, Matthew Cowan

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