May 7, 2026 · The American journal of cardiology · DOI: 10.1016/j.amjcard.2026.04.066

Severe Low Flow Aortic Stenosis with Preserved Ejection Fraction: Latest Diagnostic and Therapeutic Approach

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This review addresses the complexities of diagnosing and managing paradoxical low-flow, low-gradient aortic stenosis (pLF-LG AS), a condition characterized by severe aortic stenosis with preserved ejection fraction. The authors emphasize the need for a comprehensive diagnostic approach and highlight the importance of individualized treatment strategies, including aortic valve replacement and transcatheter aortic valve implantation, to improve patient outcomes. They aim to clarify the distinctions between true-severe and pseudo-severe disease and the implications for clinical management.

Charis Armonis, Konstantinos Triantafyllou, Elektra Papadopoulou, Athanasios Trikas

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