Clinical Predictors of Intracranial Pathology in Emergency Department Patients with Non-traumatic Headache and No Neurological Deficits: Prospective Study

This study aimed to identify clinical predictors of intracranial pathology in emergency department patients presenting with non-traumatic headaches and no neurological deficits. The authors found that headache aggravated by physical activity and age over 50 years were significant indicators of intracranial issues, particularly subarachnoid hemorrhage, while traditional symptoms like "sudden onset" and "worst headache ever" did not predict such conditions effectively. These findings could enhance clinical decision-making regarding the need for neuroimaging in this patient group.