April 24, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2601969

Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock

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This study investigates whether balanced crystalloid fluid provides better outcomes than 0.9% saline in children with septic shock. The results show no significant difference in major adverse kidney events between the two fluid resuscitation methods, suggesting that both options are similarly effective for this patient population. Additionally, the balanced fluid group experienced lower rates of hyperchloremia compared to the saline group.

Fran Balamuth, Scott L Weiss, Elliot Long, Graham C Thompson, Amanda S Artis, Atzael B Campos, Meredith L Borland, Stuart R Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P Hickey, Julie C Fitzgerald, Benjamin L Laskin, Robert W Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D Clukies, Simon Craig, Sarah J Curtis, Adrienne L Davis, Susan Duffy, Matthew A Eisenberg, Jason G Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E Gripp, Priya G Jain, Shefali Jani, Gary I Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y Kwok, Roni D Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B Freedman, Franz E Babl, Nathan Kuppermann, PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks

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May 10, 2026 · American journal of obstetrics & gynecology MFM

Dr. Jennifer Thompson

Portland, OR

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Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock

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