Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients
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The authors aimed to evaluate the effectiveness of oral nirmatrelvir-ritonavir in reducing hospitalization or death among vaccinated higher-risk outpatients with SARS-CoV-2 infection. In two open-label trials, the results indicated no significant reduction in these outcomes for participants receiving nirmatrelvir-ritonavir compared to usual care alone. Additionally, while the treatment reduced viral load, serious adverse events were reported, highlighting the need for further investigation.
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