Perioperative neurocognitive disorders: the importance of global systemic interactions
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This review article addresses the question of how perioperative neurocognitive disorders (PNDs) develop, particularly in older adults, and highlights the need for a deeper understanding of the systemic interactions that contribute to these cognitive impairments following anesthesia and surgery. The authors emphasize the potential role of extrasynaptic GABA<sub>A</sub> receptors in PNDs and advocate for a more integrated approach to studying the various factors influencing cognitive function, which may lead to more effective prevention and treatment strategies.
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