March 25, 2026 · American journal of ophthalmology · DOI: 10.1016/j.ajo.2026.03.020

Hyperreflective foci contiguous with the RPE associate with visual function in aging, early and intermediate AMD: MACUSTAR study report

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The authors aimed to investigate the relationship between hyperreflective foci contiguous with the retinal pigment epithelium (rpeHRF) and visual function impairment in aging individuals and those with early and intermediate age-related macular degeneration (AMD). Their findings indicate that the presence and burden of rpeHRF are significantly associated with poorer visual function metrics, suggesting that rpeHRF could serve as a prognostic biomarker for disease progression in AMD.

Lukas Goerdt, Vanessa Basten, Jan H Terheyden, Hannah Dunbar, Ulrich Luhmann, Nadia Zakaria, Sergio Leal, Klaus-Peter Moll, Stephen Poor, Adnan Tufail, Matthias Schmid, Robert P Finger, Steffen Schmitz-Valckenberg, Frank G Holz, Marlene Saßmannshausen, MACUSTAR consortium

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