Efficacy and safety of different vasopressor infusions on feto-maternal outcomes in normotensive patients undergoing caesarean delivery: a systematic review and network meta-analysis of randomised controlled trials
Listen to this summary
The authors aimed to evaluate the efficacy and safety of various vasopressor infusions on feto-maternal outcomes in normotensive patients undergoing caesarean delivery, given the variability in clinical practice despite guidelines favoring phenylephrine. Their systematic review and network meta-analysis of 55 randomized controlled trials found that continuous infusions of α-agonists with mild β-activity, such as noradrenaline and metaraminol, were superior to control in preventing maternal hypotension, while mephentermine and metaraminol better preserved umbilical acid-base balance. However, they noted that the evidence regarding fetal outcomes remains limited.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Anaesthesia
View all →May 5, 2026 · Anaesthesia
Artificial intelligence-assisted peri-operative echocardiography: a multicentre observational study
Apr 16, 2026 · Anaesthesia
Best practice in obstetric general anaesthesia: an umbrella review of pharmacological strategies for induction of general anaesthesia
Apr 16, 2026 · Anaesthesia
Use of sterile gowns for single-shot spinal anaesthesia: consensus guidelines from the Association of Anaesthetists, Royal College of Anaesthetists, Obstetric Anaesthetists' Association, Regional Anaesthesia UK, College of Anaesthesiologists of Ireland and Australian and New Zealand College of Anaesthetists
Apr 7, 2026 · Anaesthesia
PeriOperative Quality Initiative consensus statement recommendations on the definitions, aims and delivery of shared decision-making for major surgery
Mar 31, 2026 · Anaesthesia
Lidocaine combined with low-dose esketamine for movement-evoked pain after hepatectomy: a double-blind randomised controlled trial
Mar 29, 2026 · Anaesthesia
Patient-reported outcomes, postoperative pain and pain relief after day-case surgery (POPPY): short-term peri-operative analgesic use
More in Anesthesiology
View all →May 11, 2026 · Journal of addiction medicine
Contingency Management for Stimulant-Opioid Co-Use: A Systematic Review and Meta-Analysis
May 11, 2026 · Journal of addiction medicine
The Economic Impact of Medetomidine on Critical Care Utilization: A Longitudinal Analysis of Intensive Care Unit Charges for Opioid Withdrawal Across the Adulterated Era
May 11, 2026 · Journal of addiction medicine
Development and Testing of a Peer Recovery Support Services Intervention for Retention on Medications for Opioid Use Disorder
May 11, 2026 · Journal of addiction medicine
Prolonged Fentanyl Detection on Urine Drug Testing: A Case for Revising Interpretation Frameworks in the Setting of Chronic Use
May 10, 2026 · Lancet (London, England)
Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
May 10, 2026 · Lancet (London, England)
Impact of introducing RTS,S/AS01<sub>E</sub> malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
