Randomized trial of GvHD Prophylaxis in Haploidentical PBSC Transplantation: ATG, PTCy, and Low-Dose Combination Therapy
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The authors aimed to determine the efficacy of different graft-versus-host disease (GvHD) prophylaxis strategies in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) for patients with acute myeloid leukemia or myelodysplastic syndromes. In a randomized phase III trial involving 407 patients, they found that low-dose ATG combined with PTCy, standard-dose ATG, and PTCy alone had similar effectiveness in preventing grade II-IV acute GvHD and comparable survival rates, although the combination regimen showed significantly better neutrophil and platelet recovery.
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