March 10, 2026 · Journal of cataract and refractive surgery · DOI: 10.1097/j.jcrs.0000000000001933

Neuroprotective and Anti-Inflammatory Strategies for Corneal Nerve Regeneration and Ocular Surface Stability After Corneal Refractive Surgeries: A Systematic Review

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This systematic review aimed to evaluate the effectiveness of neuroprotective and anti-inflammatory pharmacotherapies in promoting corneal nerve regeneration and ocular surface stability following corneal refractive surgeries. The authors found that topical cyclosporine 0.05% showed the most significant benefits in enhancing nerve function and tear film stability, while other treatments yielded varying results. They concluded that further research with larger, double-masked trials is necessary to better understand the efficacy of these interventions.

Anas Alamoudi, Abdulaziz Khalid Aldahlawi, Ahmed Alnabihi, Rozan Abdulaziz AlGhamdi, Hind Mohammed Aljabri, Naif Almufarriji, Rahaf Khder Sharif, Danah Albreiki, Bader AlQahtani

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