Epigenetic clock timing in the endometrium of women undergoing IVF

The authors aimed to evaluate endometrial epigenetic age acceleration (EEAA) in women undergoing in vitro fertilization (IVF) by comparing epigenetic and chronological ages using Horvath's DNA-methylation-based clock. They found that the average endometrial epigenetic age was significantly higher than chronological age, with the most pronounced acceleration observed in younger women. This suggests that EEAA may serve as a potential biomarker for assessing endometrial health and fertility potential, warranting further research into its clinical implications.