A 'target trial emulation' of prehospital sublingual nitroglycerin administration for suspected acute coronary syndrome

The authors aimed to evaluate the association between prehospital administration of sublingual nitroglycerin and outcomes in patients with suspected acute coronary syndrome (ACS) using a nationwide dataset. Their analysis of 70,890 patients found that nitroglycerin administration did not significantly reduce the composite outcome of critical interventions such as CPR or defibrillation, suggesting that its effectiveness in this setting may be limited. The study highlights the need for further research, given the low prevalence of the outcomes assessed and the observational nature of the data.