March 7, 2026 · Prenatal diagnosis · DOI: 10.1002/pd.70109

Diagnostic Yield of Post-Mortem Fetal Micro-CT for Central Nervous System Abnormalities

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This study investigates the effectiveness of post-mortem fetal micro-focus computed tomography (Micro-CT) in detecting central nervous system (CNS) abnormalities in fetuses following pregnancy loss. Analyzing 1200 scans, the authors found that Micro-CT identified 78 CNS abnormalities in 62 fetuses, with neural tube defects and ventriculomegaly being the most common. The findings suggest that Micro-CT is a valuable diagnostic tool for identifying a range of CNS abnormalities, even in cases with significant tissue maceration.

Ian C Simcock, Audrey Lamouroux, Susan C Shelmerdine, J Ciaran Hutchinson, Neil J Sebire, Owen J Arthurs

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