First-Trimester Down Syndrome Screening in Renal-Transplanted Pregnant Women: Blood Creatinine Levels Impact False-Positive Rate

This study aimed to evaluate the effectiveness of first-trimester Down syndrome screening in pregnant women who have undergone kidney transplantation and to investigate the influence of renal function, specifically blood creatinine levels, on the screening outcomes. The authors found that while the median values of free-βhCG differed significantly between the transplant group and controls, the screen positive rate was notably higher in the transplant group, indicating that renal function impacts screening results. Overall, the research highlights the need for tailored screening approaches in this unique patient population.