Clinical and inflammatory profiles in substance use disorder: gender, substance type, and comorbidity in a single-center cross-sectional study in Turkey

The authors aimed to investigate the clinical and inflammatory profiles associated with substance use disorder (SUD) in a Turkish inpatient population, focusing on how these profiles vary by substance type, gender, and comorbidity. Their findings indicate that inflammatory biomarkers, particularly the Inflammatory Burden Index (IBI) and C-reactive protein (CRP), are significantly elevated in users of methamphetamine, alcohol, and MDMA, with gender differences reflecting broader international trends. The study underscores the biological heterogeneity in SUD and suggests the need for further research to explore the relationship between inflammation and cognitive vulnerability.