March 4, 2026 · Journal of addictive diseases · DOI: 10.1080/10550887.2026.2626423

Network meta-analysis of non-pharmacological interventions for psychiatric symptoms among individuals with substance use disorders

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The authors aimed to evaluate the comparative efficacy of non-pharmacological interventions (NPIs) for reducing depression, anxiety, and substance craving in individuals with substance use disorders (SUDs). Their network meta-analysis of 24 randomized controlled trials found that exercise therapy was the most effective for alleviating depression, while cognitive-behavioral therapy showed particular effectiveness for anxiety related to opioid use disorder. The study suggests integrating various NPIs into addiction treatment to improve patient outcomes.

Hongjie Li, Xu Gao

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