Multi-omics Analysis Reveals Distinct Changes in the Cellular Composition of Vulvar Lichen Sclerosus

This study aimed to investigate the cellular composition and gene/pathway alterations in vulvar lichen sclerosus (VLS) tissue compared to normal skin using single-cell RNA sequencing and lipid metabolomics. The authors found significant increases in T cell abundance and alterations in key metabolic and inflammatory gene expressions in VLS, indicating an ongoing inflammatory process that contributes to skin tissue destruction. These findings highlight the critical role of T cell-mediated immunity in the pathogenesis of VLS.