Upadacitinib for the Treatment of Recalcitrant Vulvar Lichen Sclerosus

The authors investigate the efficacy of oral upadacitinib as a treatment for recalcitrant vulvar lichen sclerosus, a condition with limited treatment options beyond topical steroids. In a retrospective case series involving three patients, all experienced clinical improvement and reduced symptoms with minimal side effects. The study suggests that upadacitinib may be a promising alternative for managing this challenging condition, though further research is necessary to confirm its effectiveness.