Accuracy of HPV Testing Using Self-collected Urine Compared With Physician-collected Cervical Specimen for HSIL or Worse

The authors aimed to evaluate the accuracy of HPV testing using self-collected urine samples compared to physician-collected cervical specimens for detecting high-grade squamous intraepithelial lesions (HSIL+) as part of efforts to improve cervical cancer screening. Their meta-analysis of 23 studies found that while self-collected urine had a sensitivity of 84.5%, physician-collected samples were more accurate at 92.1%. The study suggests that first-void urine collected with a standard device may slightly enhance sensitivity, but overall, physician-collected specimens remain superior for HSIL+ detection.