September 8, 2026 · Regional anesthesia and pain medicine · DOI: 10.1136/rapm-2025-107223

Complications leading to device explant in patients with chronic non-cancer pain receiving intrathecal drug delivery

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This study aims to characterize the complications leading to device explant in patients with chronic non-cancer pain receiving intrathecal drug delivery (IDD). The findings reveal that device-related infections are the primary cause of explants, occurring in 9.3% of patients, while loss of analgesic efficacy was less frequent compared to similar complications seen with spinal cord stimulation. Overall, the explant rate was 26.1%, with no significant demographic or comorbidity factors correlating with the need for explantation.

Salim Michel Hayek, Sameam Shahrestani, Jacob Blank, Beatriz Feijo, Jose Reyes, Phu Duong, Muskan Sidhu, Qiuchen Li, Ryan Shaner, Jennifer Murphy, Michael D Staudt

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