September 8, 2026 · Regional anesthesia and pain medicine · DOI: 10.1136/rapm-2026-108095

Historical perspective on evolution of neuraxial delivery for pain (1975-2025)

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The authors examine the historical development of neuraxial delivery methods for pain management over the past 50 years, aiming to understand how advancements in this field have shaped current practices. They reflect on the evolution of neuraxially targeted therapeutics and speculate on future directions for pain management in the 21st century.

Tony Yaksh, Salim Michel Hayek

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