The association of maternal obesity and gestational diabetes during pregnancy with offspring adiposity and dysmetabolism: the Intergenerational Transmission of Obesity (ITO) study
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The study aimed to investigate how maternal obesity and gestational diabetes mellitus (GDM) during pregnancy influence offspring adiposity and metabolic health. By analyzing data from a cohort of pregnant individuals, the authors found that maternal GDM and obesity were linked to increased neonatal size and specific metabolic markers, with maternal triglycerides emerging as a significant predictor of adverse outcomes. The results highlight the need for metabolic optimization prior to conception to reduce the risk of obesity and metabolic diseases in future generations.
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