June 17, 2026 · The Journal of bone and joint surgery. American volume · DOI: 10.2106/JBJS.25.01100

Heading Toward a Different Future: The Microbiome, Dysbiosis, Microbial Translocation, and Beyond

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This paper explores the emerging concept of the gut-joint axis, investigating how dysbiosis and microbial translocation from the gut may contribute to joint diseases. The authors aim to understand the mechanisms linking gut health to these conditions and propose that future research should focus on developing therapeutic strategies to restore gut barrier integrity and microbiota diversity. They emphasize the need for advanced research methodologies, such as next-generation sequencing, to facilitate this understanding.

Mincong He, Augusto Ferrini, Emanuele Chisari, Frank Kolhoff, Priya Sehgal, Javad Parvizi

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