June 10, 2026 · International journal of radiation oncology, biology, physics · DOI: 10.1016/j.ijrobp.2026.05.058

Development and dosimetric characterization of an in vitro benchtop Am-241 alpha irradiator platform

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The authors aimed to develop and characterize a benchtop in vitro alpha irradiation platform using an Americium-241 source to facilitate preclinical studies on the radiobiology of alpha particles in cancer therapy. They successfully constructed a system that ensures dose homogeneity and stability, demonstrating feasibility for controlled alpha particle irradiation with consistent dose rates. This platform is designed to support high-throughput research and long-term investigations into the effects of alpha radiation.

Sean P Jollota, Sonja Dragojevic, Nicholas B Remmes, Jeffery L Radtke, Jasvinder Singh, Larry A DeWerd, Gabriel O Sawakuchi, Marco T F Reis, Mukesh K Pandey, Zhenkun Lou, Robert W Mutter, Ahtesham U Khan, Cameron M Callaghan

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