International journal of radiation oncology, biology, physics
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PET-Guided Modeling of Mucosal Boron Heterogeneity Improves Dose-Toxicity Prediction in BNCT

Jun 11, 2026

The authors aimed to determine if mucosal boron heterogeneity, as measured by fluoro-boronophenylalanine positron emission tomography (18F-BPA PET), can enhance the prediction of oral mucositis in patients undergoing boron neutron capture therapy (BNCT) for head and neck cancer. Their findings indicated that the uptake-defined biological dose metric (D0.05cc) significantly correlated with toxicity outcomes, outperforming traditional anatomical dose calculations based on uniform boron distribution. This suggests that incorporating functional imaging may improve patient-specific dose constraints and toxicity predictions in BNCT.

Characteristics of Crowdfunding Campaigns for Proton Therapy

Jun 11, 2026

The authors aimed to identify the characteristics of crowdfunding campaigns for proton therapy that successfully met their fundraising goals. Analyzing 699 GoFundMe campaigns, they found that campaigns associated with uninsured patients and those providing additional information about treatment were more likely to be fully funded. The study highlights crowdfunding as a potential financial safety net for cancer patients, influenced by factors such as patient demographics and insurance coverage.

Development and dosimetric characterization of an in vitro benchtop Am-241 alpha irradiator platform

Jun 10, 2026

The authors aimed to develop and characterize a benchtop in vitro alpha irradiation platform using an Americium-241 source to facilitate preclinical studies on the radiobiology of alpha particles in cancer therapy. They successfully constructed a system that ensures dose homogeneity and stability, demonstrating feasibility for controlled alpha particle irradiation with consistent dose rates. This platform is designed to support high-throughput research and long-term investigations into the effects of alpha radiation.