The Sensitivity, Specificity, and Predictive Values of Serum Angiotensin-Converting Enzyme and Lysozyme in the Diagnosis of Sarcoid Optic Neuropathy
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This study investigates the diagnostic performance of serum angiotensin-converting enzyme (s-ACE) and serum lysozyme in identifying sarcoid optic neuropathy (SON). The authors found that while both tests exhibited high specificity (97% for s-ACE and 98% for lysozyme), their sensitivity was low (21.4% for s-ACE and 33.3% for lysozyme), indicating that these biomarkers are not effective as general screening tools for SON.
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