June 10, 2026 · The American journal of clinical nutrition · DOI: 10.1016/j.ajcnut.2026.101392

Circulating palmitoleic acid is associated with cerebral glucose metabolism in healthy middle-aged individuals: results from the PESA prospective cohort study

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The authors aimed to investigate the relationship between circulating palmitoleic acid (POA), a biomarker of de novo lipogenesis, and cerebral glucose metabolism in healthy middle-aged individuals. Their findings revealed that higher levels of RBC POA were associated with lower cerebral glucose uptake both cross-sectionally and longitudinally, suggesting that dietary habits influencing POA levels may play a crucial role in maintaining brain health and preventing cognitive decline.

Aleix Sala-Vila, Catarina Tristão-Pereira, Iolanda Lázaro, Mehrnaz Shekari, Alberto Fernández-Pena, Jennifer Monereo-Sánchez, Ines Garcia-Lunar, Cristina Perez-Herreras, Maria Angeles Moro, Ana Garcia-Alvarez, Javier Sanchez-Gonzalez, Juan Domingo Gispert, Borja Ibanez, Valentin Fuster, Marta Cortes-Canteli

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