Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure

This study aims to determine whether first-episode psychosis differs in clinical presentation, biology, and illness course between individuals with cannabis exposure (CAP) and those without (NCAP). The findings indicate that CAP participants showed better cognitive improvement and distinct symptom profiles, including lower negative symptoms and higher mood symptoms, compared to NCAP. Additionally, resuming cannabis use was linked to a higher risk of relapse, suggesting that cannabis-associated psychosis may represent a unique subtype of first-episode psychosis.